Shunting of insulin from a retroendocytotic pathway to a degradative pathway by sodium vanadate.
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Shunting of insulin from a retroendocytotic pathway to a degradative pathway by sodium vanadate.
Adipocytes route internalized insulin through two major pathways, a degradative pathway and a retroendocytotic pathway. To examine whether sorting of incoming insulin-receptor complexes can be altered, we assessed the effect of vanadate on the intracellular processing of both insulin and insulin receptors. After cells were pretreated with vanadate (1 mM for 30 min at 37 degrees C), 125I-insulin...
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15 صفحه اولThe insulin-like effect of sodium vanadate
Sodium vanadate has several insulin-like effects. To determine whether vanadate acts via the insulin receptor, I investigated the effect of vanadate on glucose transport (2-deoxyglucose uptake) in adipocytes that had been treated to decrease the number of insulin receptors. (1) Trypsin (100 ,tg/ml) caused > 95% loss of 1251-insulin binding and rendered glucose transport resistant to both insuli...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1987
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)45310-0